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IT Manager



San Diego, CA, USA
Posted on Tuesday, July 9, 2024

About Plexium:

Plexium is the premier, next-generation Targeted Protein Degradation (TPD) company focused on the discovery of TPD drugs which overcome limitations of conventional approaches to broaden the therapeutic potential of TPD. Plexium is pursuing monovalent degraders, including a new class of selective TPD drugs called “Direct Degraders.” Direct Degraders are small molecules that are designed to bind to a pathogenic protein in a manner that results in selective degradation of the protein by the cell’s natural protein quality control machinery. In addition to direct degraders, Plexium is pursuing molecular glue degraders. This approach also leverages the cell’s natural quality control machinery, however in this case, small molecules bind to an E3 ligase, redirecting the ligase to selectively target pathogenic proteins for degradation. Plexium is pursuing drug targets that have previously been undruggable or inadequately drugged across multiple disease areas.

Plexium is powered by its proprietary TPD drug discovery platform, which integrates degrader chemistry design principles and screening libraries with cell-based, target-specific degradation assays, including an ultra-high-throughput screening platform, to enable the identification of drug-like, cell-permeable degrader molecules. This integrated TPD drug discovery approach has led to the discovery of novel, selective direct degraders and molecular glue drug candidates, and two unprecedented E3 ligases.

The IT Manager is to be the point IT resource for a biotechnology drug discovery and development company. The position will work closely with technology and informatics teams while maintaining the corporate backbone infrastructure and supporting users on a day-to-day basis. The IT Manager will combine technical skills with budget/administrative skills as well as people skills to support the continued progress of Plexium. The IT Manager supports and maintains in-house computer systems, desktops, and peripherals. Responsibilities include: supporting and maintaining the stable operation of the computer network, installing, diagnosing, repairing, maintaining, and upgrading all hardware and equipment while ensuring optimal network and end-client performance. The IT Manager is responsible for resolving problems in a timely and accurate fashion, and providing end user training, help desk services and assistance where required. The IT Manager will maintain awareness of best practices and production trends, assess potential impact on operational outcomes, and develop and execute plans to adapt operations to capture the improvements over the long-range plan horizon.They will also identify and monitor key performance indicators, recommend and implement corrective action, and provide the regulatory governance and oversight surrounding Plexium’s on-premises and cloud infrastructure.

Job Responsibilities:

  • Analyze, design, acquire, define, and implement network, cloud, security, storage and communications systems and solutions
  • Lead and plan the day-to-day execution of infrastructure and cloud operations, policies, processes and support
  • Coordinate incident and issue resolution across critical IT functions
  • Prepare schedules, monthly status report, and security overviews
  • Manages connectivity to cloud and hosted environments
  • Oversees Plexium’s Security Systems and security compliance
  • Performs network administration (including backup, security management, user account management, e-mail systems including e-mail web server, internet access, office systems and applications support)
  • Support and Maintain O365 Environment
  • Supports server, network and desktop hardware, software and application
  • Performs technology needs analysis by conferring with departmental personnel to analyze current operational procedures, identify problems, and learn specific input and output requirements
  • Rolls out hardware and software to ensure optimal deployment of resources
  • Plans, implements, and supports the network and computing infrastructure plan
  • Manages projects according to agree upon budgets and schedules
  • Manages software licensing agreements, renewals and purchases
  • Evaluate existing and new 3rd party vendors against internal capabilities, the vendor landscape and cost/benefits
  • Documents configurations of Servers, Networks, WAN and Security
  • Manages and schedules repairs, maintenance and upgrades for network, infrastructure and cloud operations
  • Manages IT helpdesk and vendors
  • Manages Audio/Visual and Conferencing Systems


  • Technology knowledge of Server, Network and Security systems
  • Working technical knowledge of current network protocols, operating systems, and standards
  • Ability to operate tools, components, and peripheral accessories
  • Able to read and understand technical manuals, procedural documentation, and OEM guides
  • Ability to conduct research into PC issues and products as required
  • Ability to present ideas in user-friendly language
  • Strong customer-service orientation
  • Basic budget management skills
  • Responsible for technical support of the IT infrastructure, hardware maintenance, patch management, information security, change management, wide and local area networks, server infrastructure, and network operations

Education and Qualifications:

  • Bachelor's degree in Computer Science, Information Systems, or Engineering preferred
  • 7+ years of experience working in IT environment
  • Experience with:
    • Server, Network and Security Systems
    • PCs, tablets and peripherals
    • Office 365
    • Web and Cloud Applications
    • Voice, Internet and Cloud Services

The US base salary range for this full-time position is $115,000-$165,000 + target annual bonus + equity + health and well-being benefits. Our salary ranges are determined by a number of factors, including but not limited to the role, location, job-related skills, and relevant education, experience and training. The range displayed on each job posting reflects the minimum and maximum target for new hire base salaries for the position across all US locations and vary by the location of the position. Our Human Resources Team can share more about our salary ranges and other benefits of working at Plexium, which are not included in the posted base salary range.

Notice to third party recruitment agencies: Plexium does not accept unsolicited resumes from recruiters or employment agencies. In the absence of an executed recruitment services agreement, there will be no obligation to any referral compensation or recruiter fee. In the event a recruiter or agency submits a resume or candidate without an agreement Plexium shall explicitly reserve the right to pursue and hire those candidate(s) without any financial obligation to the recruiter or agency. Any unsolicited resumes, including those submitted to hiring managers, shall be deemed the property of Plexium.