Research Associate/Sr. Research Associate/Associate Scientist, Immunology
GenEdit is a rapidly growing, early-stage company that is developing a proprietary and novel delivery platform with the potential to transform genetic medicine. Our interdisciplinary team works together across chemistry, payload, formulation, screening, and preclinical groups to develop the next generation of gene therapies. GenEdit fosters an exciting and dynamic environment where we value impactful data and creative solutions to accelerate our progression from a platform technology to a pipeline of therapeutic candidates. We are seeking talented and motivated individuals to join our team and are expanding across all functions within the organization. Join us in South San Francisco, CA, to be at the forefront of the future of gene therapy.
Job Description
GenEdit is seeking a highly self-motivated, multi-talented and goal-oriented Research Associate/SRA with hands-on experience in performing the cell-based assays using mammalian immune, primary cells and cell lines. The position will be responsible for characterizing GenEdit’s novel polymer nanoparticles across a wide array of cell types to deliver genetic medicines, including mRNA, siRNA, and Cas9. The successful candidate will have experience handling multiple types of mammalian cell cultures, for example Immune cells, PBMC,HSPC, neural cells, and will have experience performing various microplate-based assays, such as viability/toxicity, fluorescence, luminescence, and automated microscopy. Characterization of payload activity will include molecular biological methods such as the nucleic acid extraction, PCR, RT-qPCR, and immunoassays such as ELISA, ELISpot, Flow cytometry and Western Blot. This position will work cooperatively with multidisciplinary teams, keep detailed and organized lab records, and present results at team meetings.
Under the direction of the project leader/immunology manager, this lab-based position will work closely with colleagues on project teams advancing our novel gene delivery system for therapeutic applications in immune-based diseases.
Education and Qualifications:
● Bachelor or Master’s degree Immunology, Cell & Molecular Biology, Biotechnology, Biochemistry, Biomedical Engineering, or related subject with 1-2 years (For Technician/RA), 2-3 years (for Senior RA), and 3-4 years (for Associate Scientist) of scientific/pharma/academic research experience
● >2 years wet lab research experience in Immunology
● Work authorization in the US is required
Desired Skill Sets:
● Experience with cell culture/characterization of various immune cells (DC, Macrophages) and primary cells (PBMC, iPSC, HSPC) and neural cells.
● Experience with multicolor Flow Cytometry
● Experience with molecular and cellular biology techniques such as DNA, RNA and Protein extraction and purification, Electrophoresis, Primer design, PCR, Real Time-qPCR, DNA sequence analysis, ELISA, ELISpot and Western Blot
● Experience with microplate cell-based assays, in vitro screening, immunocytochemistry, cytotoxicity assay, and quantitative microscopy
● Experience with Prism and FlowJo for data analysis
● Excellent written and oral communications skills a plus familiarity with SOP writing
● Excellent organization and use of network drives
● Ability to execute on standard operating procedures with accuracy and precision
● A creative and proactive approach to problem-solving.
