GenEdit is a rapidly growing, early-stage company that is developing a proprietary and novel delivery platform with the potential to transform genetic medicine. Our interdisciplinary team works together across chemistry, payload design, formulation, and screening and preclinical groups to develop the next generation of gene therapies. GenEdit fosters an exciting and dynamic environment where we value impactful data and creative solutions to accelerate our progression from platform technology to a pipeline of therapeutic candidates. We are seeking talented and motivated individuals to join our team and are expanding across all functions within the organization. Join us in South San Francisco, CA, to be at the forefront of the future of gene therapy.
Job Description
This position will report to the Principal Scientist in the Product and Process Development team, who is leading our efforts to develop and apply DNA barcoding technologies for efficient and high throughput measurement of non-viral vector distributions across organs, tissues and cell types in small and large animals. This barcoding technology will be part of GenEdit’s platform program to screen in vivo and identify hydrophilic nanoparticles (HNP) that enables cell-specific delivery of genetic medicines. The barcode technology will allow rapid and simultaneous tracking of multiple gene vectors in one animal in vivo and allows fast discovery of tissue and cell-specific HNPs for clinical applications in gene therapy.
Responsibilities
· Lab: Aid in the implementation of DNA barcode technology such extractions from animal tissues, PCR amplification of DNA and sending samples for NGS
· Study Designs: Provide support for experimental design and execution including the further development of barcode design, PCR/primer design and amplification, and statistical analysis
· Computational: Preferred but not required to have proficiency in bioinformatics including statistical programming language (R, python, etc.) and data science
· Collaboration and communication: Work cooperatively with peers and multidisciplinary teams, keep detailed and organized lab records, and present results at team, internal company, and external alliance meetings.
Experience and Requirements
· PhD, MS, or BS in molecular biology, biochemistry, biomedical engineering, or a related field
· Extensive experience with molecular biology, design, and generation of DNA & mRNA libraries and NGS
· Industry experience 1+ years preferred
· Experience using various in vitro expression systems and in vivo models.
Knowledge and hands-on experience with CRISPR-Cas9 or nucleic acid delivery a plus
Experience in primary cell culture or nanoparticle formulation is plus
· Some experience with using Python or other scripts for data analysis
· Highly motivated scientist with attention to detail and the ability to independently plan, design and implement experiments
· Work authorization in the US required.
