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Research Associate/Sr. Research Associate, Chemical Biology

Frontier Medicines

Frontier Medicines

Other Engineering
Boston, MA, USA
Posted on Thursday, October 12, 2023

Frontier Medicines is seeking a highly motivated Research Associate/Senior Research Associate with expertise in proteomics and mass spectrometry to join our Chemical Biology group. The successful candidate will be responsible for performing chemical biology assays across a variety of disciplines and techniques to drive drug discovery. Experience with activity-based protein profiling and chemoproteomics is highly desirable.

This individual will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management. This position provides exposure to cutting edge chemoproteomics technologies and offers professional development opportunities in drug discovery. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in a dynamic team environment driven to deliver quality data to enable drug discovery. This position is located in Boston.

What will you be doing?

  • Execute mass spectrometry-based assays for lead identification, optimization, and characterization with a high level of independence.
  • Develop and execute activity-based protein profiling assays for target-engagement assessment and selectivity profiling (gel-based, proteomics, etc.).
  • Maintain and operate HPLC and LC-MS instruments to ensure steady performance and high productivity.
  • Troubleshoot and optimize experiments to ensure generation of high-quality data.
  • Routinely use automation and liquid-handlers to execute key assays.
  • Analyze data and provide updates to project teams while meeting timelines and goals.
  • Maintain a clear, detailed laboratory notebook to document all experiments and findings.
  • Comply with best laboratory safety practices.

What are we looking for?

  • B.S. or Master’s degree in Chemical Biology/Biochemistry, Chemistry, Cell/Molecular Biology/Biotechnology, or related field with 2+ years industry/academic lab experience preferred.
  • Hands-on expertise with liquid chromatography and mass spectrometry is preferred.
  • Proteomics sample preparation experience with enzymatic digestion/lysate characterization, protein precipitation, Tandem mass tags (TMT) labeling, activity-based protein profiling (ABPP), is highly desirable.
  • Experience with cell culture, gel electrophoresis and western blot is highly desirable.
  • Experience with liquid-handling and automation is a plus.
  • The candidate should be driven, have a desire to achieve excellence, and thrive in a dynamic start-up environment.
  • Excellent communication, organization, time management, and technical writing skills.
  • Strong problem-solving skills and ability/desire to learn new skills.
  • Research Associate level will be determined based on level of experience.
  • Legally authorized to work in the US.
  • Health Care Plan (Medical, Dental & Vision)
  • Retirement Plan (401k, IRA)
  • Life Insurance (Basic, Voluntary & AD&D)
  • Paid Time Off (Vacation, Sick & Public Holidays)
  • Family Leave (Maternity, Paternity)
  • Short Term & Long Term Disability
  • Training & Development
  • Free Food & Snacks
  • Wellness Resources
  • Stock Option Plan

At Frontier we strive to build a diverse and equitable workplace. The salary range for this role is $82,000 – $105,000. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits.

This compensation and benefits information is based on Frontier’s knowledge as of the date of publication, and may be modified in the future.