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Sr. Scientist, Structural Biology

Frontier Medicines

Frontier Medicines

South San Francisco, CA, USA
Posted on Saturday, October 7, 2023

The Structural Biology group has an exciting opportunity for a Senior Scientist with extensive hands-on experience in protein chemistry and crystallography. We are looking for a highly motivated individual who wants to make a lasting impact to patients’ lives. The successful candidate will represent the Structural Biology group and work with a diverse team of scientists to advance our small-molecule drug discovery programs. This scientist will be responsible for design, production, and crystallization of proteins and protein-ligand complexes to enable structural studies by X-ray crystallography and/or cryo-EM. This scientist will also play a critical role in the development of Frontier’s technology platform including covalent fragment-based lead finding. This scientist will have the opportunity to build and manage a small internal group as well as external CROs. The position will report to the Executive Director of Structural Biology and Protein Sciences and is located in South San Francisco

What will you be doing?

  • Provide leadership to structurally enable a broad range of targets across different therapeutic areas. Establish robust gene-to-structure protocols to support structure-based drug design.
  • The primary focus is to produce high grade protein samples and achieve crystallization; contribute to the design, expression and purification of recombinant proteins.
  • Partner with protein chemists, biophysicists, computational chemists, medicinal chemists, and biologists. Regularly present experimental results to project teams and external collaborators.
  • Improve existing technologies and incorporate new technologies in relevant fields.
  • Build and manage a small research group.
  • Manage domestic and international CROs.

Traits we believe make a strong candidate:

  • Ph.D. in Structural Biology, Biophysics, Biochemistry or other relevant fields with 5+ years of post-Ph.D. experience. Industrial structure-based drug design experience is highly preferred. Applicants holding an M.S. degree must have 10+ years of relevant experience.
  • Hands-on experience with protein crystallization utilizing robotic and manual methods. Training in diffraction data collection and data processing is a plus.
  • Solid technical background with protein production methodology, techniques and instrumentation, as demonstrated in peer-reviewed publications.
  • Broad experience with macromolecular crystallography, strong track-record in optimizing the expression, purification and crystallization of challenging proteins through protein engineering, and ability to propose new approaches and ideas is highly desired.
  • Experience with cryo-EM is a plus.
  • Ability to work in a fast-paced team environment, meet deadlines, and prioritize work from multiple projects.
  • Strong interpersonal, written and verbal communication skills; productive and collaborative interactions with other members of a multi-site, cross-functional organization.
  • Legally authorized to work in the U.S.
  • Health Care Plan (Medical, Dental & Vision)
  • Retirement Plan (401k, IRA)
  • Life Insurance (Basic, Voluntary & AD&D)
  • Paid Time Off (Vacation, Sick & Public Holidays)
  • Family Leave (Maternity, Paternity)
  • Short Term & Long Term Disability
  • Training & Development
  • Free Food & Snacks
  • Wellness Resources
  • Stock Option Plan

At Frontier we strive to build a diverse and equitable workplace. The salary range for this role is $130,000 – $170,000. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits.

This compensation and benefits information is based on Frontier’s knowledge as of the date of publication, and may be modified in the future.