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Sr. Scientist/Principal Scientist, Medicinal Chemistry

Frontier Medicines

Frontier Medicines

Boston, MA, USA
Posted on Saturday, January 7, 2023

What’s in it for you?

We are seeking a highly motivated individual, based on experience, to fill the position of Sr. or Principal Scientist, Medicinal Chemistry to join our medicinal chemistry team in Boston, MA. This person will play a key role tackling challenging disease targets applying a variety of small molecule strategies including covalent inhibitor drug discovery and the application of a novel protein degrader technology. The team is focused on the discovery of new medicines to treat cancers and other serious disorders. The successful candidate will drive the design and synthesis of lead compounds, apply a high understanding of medicinal chemistry, contribute to the management of external chemistry activities, and bring practical leading-edge methods to Frontier Medicines discovery programs.

What will you be doing?

  • Apply organic and medicinal chemistry skills in the design and synthesis of novel small molecules as potential drug candidates
  • Closely follow emerging results of biological testing, ADME characterization, and other lead profiling assays; proactively propose new strategies and new target molecules to improve key drug attributes.
  • May lead a team of scientists or research associates contributing to a high caliber scientific and collaborative culture.
  • Proactively help manage external chemistry efforts, providing synthetic expertise in a collaborative fashion.
  • Regularly summarize results and provide progress updates to the chemistry, cross-functional project teams.
  • May develop to a Chemistry Team Lead or Project Team Lead for the target pipeline leading a matrixed-based team to selection of a development candidate
  • Contribute to the writing of patent applications, study reports, and scientific publications.

What are we looking for?

  • Ph.D. in organic or medicinal chemistry with a minimum 5 years or MSc. with a minimum 10 years progression growth in a biotech or pharma setting.
  • Extensive working knowledge of modern medicinal chemistry and drug discovery techniques (e.g., fragment and structure-based drug design, computational chemistry, multi-parametric optimization of bioactivity/physicochemical/ADME properties).
  • Strong background in complex molecule synthesis and/or methods development experience with a wide range of techniques related to multi-step synthesis, purification, and characterization.
  • Demonstrated track record of patents and publications in medicinal chemistry.
  • Strong drug discovery achievements at individual or team-level of delivering novel agents toward clinical development.
  • Ability to work with and manage multifunction teams.
  • Project leadership experience is desirable but not essential.
  • Self-motivated and enthusiastic; fast learner who can identify the core project challenges and expeditiously change course as required in a fast-paced organization.
  • Team player who will be able to collaborate effectively in a multi-disciplinary environment.
  • A commitment to excellence, maintaining detailed records and having superb data organization skills.
  • Legally authorized to work in the US.
  • Health Care Plan (Medical, Dental & Vision)
  • Retirement Plan (401k, IRA)
  • Life Insurance (Basic, Voluntary & AD&D)
  • Paid Time Off (Vacation, Sick & Public Holidays)
  • Family Leave (Maternity, Paternity)
  • Short Term & Long Term Disability
  • Training & Development
  • Free Food & Snacks
  • Wellness Resources
  • Stock Option Plan

At Frontier we strive to build a diverse and equitable workplace. The salary range for this role is $145,000 – $205,000. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits.

This compensation and benefits information is based on Frontier’s knowledge as of the date of publication, and may be modified in the future.